Home / Caspase-1 / Caspase-1/ICE Colorimetric Assay Kit

Caspase-1/ICE Colorimetric Assay Kit

Catalog #: K111-100
9 Citations Datasheet / COA / SDS

Discontinued Product

K111-100 has been discontinued.
View all Caspase-1 products.
Product Details
Citations (9)
FAQs
Reviews
Summary Product Datasheets Background

Caspase-1/ICE Colorimetric Assay Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

Product Datasheets

You must select a language.

x
Product Datasheet
COA
SDS

Background: Caspase-1

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
834 (Human)
Alternate Names
CASP1 nirs variant 1; CASP1; CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase-1 subunit p10; Caspase-1 subunit p20; Caspase1; Caspase-1; EC 3.4.22.36; EC:3.4.22.36; ICE; IL-1 beta-converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45

Citations for Caspase-1/ICE Colorimetric Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
Filter your results:

Filter by:

  1. Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2
    Authors: T Feng, X Zhao, P Gu, W Yang, C Wang, Q Guo, Q Long, Q Liu, Y Cheng, J Li, CKY Cheung, D Wu, X Kong, Y Xu, D Ye, S Hua, K Loomes, A Xu, X Hui
    Nature Communications, 2022-09-05;13(1):5208.  2022-09-05
  2. NLRP3 Inflammasome Activation Controls Vascular Smooth Muscle Cells Phenotypic Switch in Atherosclerosis
    Authors: F Burger, D Baptista, A Roth, RF da Silva, F Montecucco, F Mach, KJ Brandt, K Miteva
    International Journal of Molecular Sciences, 2021-12-29;23(1):.  2021-12-29
  3. TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
    Authors: S Ranta-Aho, N Piippo, E Korhonen, K Kaarnirant, M Hytti, A Kauppinen
    International Journal of Molecular Sciences, 2021-05-05;22(9):.  2021-05-05
  4. The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1&beta and IL-18 secretion
    Authors: S Sukhanov, Y Higashi, T Yoshida, S Mummidi, AR Aroor, J Jeffrey Ru, SB Bender, VG DeMarco, B Chandrasek
    Cell Signal, 2020-11-04;77(0):109825.  2020-11-04
  5. Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis
    Authors: HH Jarosz-Gri, T Scambler, CH Wong, S Lara-Reyna, J Holbrook, F Martinon, S Savic, P Whitaker, C Etheringto, G Spoletini, I Clifton, A Mehta, MF McDermott, D Peckham
    Elife, 2020-03-02;9(0):.  2020-03-02
  6. Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of ?-amyloid
    Authors: A Rubio-Arai, OM Finucane, S Keogh, MA Lynch
    J Neuroinflammation, 2018-08-31;15(1):247.  2018-08-31
  7. Cysteine ameliorates allergic inflammatory reactions by suppressing thymic stromal lymphopoietin production in activated human mast cells
    Authors: SY Nam, HM Kim, HJ Jeong
    Nutr Res, 2017-12-01;49(0):79-87.  2017-12-01
  8. The TIR/BB-loop Mimetic AS-1 Prevents Nonalcoholic Steatohepatitis and Hepatic Insulin Resistance by Inhibiting NLRP3-ASC Inflammasome Activation
    Authors: X Wang, Y Gao, J Song, C Tang, M Wang, L Que, L Liu, G Zhu, Q Chen, Y Yao, Y Xu, J Li, Y Li
    Br. J. Pharmacol, 2017-04-26;0(0):.  2017-04-26
  9. Atractylone, an active constituent of KMP6, attenuates allergic inflammation on allergic rhinitis in vitro and in vivo models
    Mol Immunol, 2016-09-13;78(0):121-132.  2016-09-13

FAQs

No product specific FAQs exist for this product, however you may

View all Activity Assay FAQs

Reviews for Caspase-1/ICE Colorimetric Assay Kit

There are currently no reviews for this product. Be the first to review Caspase-1/ICE Colorimetric Assay Kit and earn rewards!

Have you used Caspase-1/ICE Colorimetric Assay Kit?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review