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Caspase-8 Fluorometric Assay Kit

Catalog #: K112-100
17 Citations Datasheet / COA / SDS

Discontinued Product

K112-100 has been discontinued.
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Citations (17)
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Caspase-8 Fluorometric Assay Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-Species

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Background: Caspase-8

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
841 (Human); 12370 (Mouse)
Alternate Names
AIS; androgen receptor; CASP8; Caspase8; Caspase-8; DHTRTFM; Dihydrotestosterone receptorHYSP1; HUMARA; Mch5; NR3C4KD; Nuclear receptor subfamily 3 group C member 4; SMAX1SBMA; spinal and bulbar muscular atrophy

Citations for Caspase-8 Fluorometric Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

17 Citations: Showing 1 - 10
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  1. The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
    Authors: IC Etti, R Abdullah, A Kadir, NM Hashim, SK Yeap, MU Imam, F Ramli, I Malami, KL Lam, U Etti, P Waziri, M Rahman
    PLoS ONE, 2017-08-03;12(8):e0182357.  2017-08-03
  2. Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
    Authors: IC Etti, A Rasedee, NM Hashim, AB Abdul, A Kadir, SK Yeap, P Waziri, I Malami, KL Lim, CJ Etti
    Drug Des Devel Ther, 2017-03-20;11(0):865-879.  2017-03-20
  3. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
    Authors: MJ Mitchell, J Webster, A Chung, PP Guimarães, OF Khan, R Langer
    Nat Commun, 2017-03-20;8(0):14179.  2017-03-20
  4. Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.
    Authors: Preyat N, Rossi M, Kers J, Chen L, Bertin J, Gough P, Le Moine A, Rongvaux A, Van Gool F, Leo O
    Cell Death Differ, 2015-05-22;23(1):29-40.  2015-05-22
  5. A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
    Authors: Chiang, Nai-Jung, Lin, Ching-I, Liou, Jing-Pin, Kuo, Ching-Ch, Chang, Chi-Yen, Chen, Li-Tzong, Chang, Jang-Yan
    PLoS ONE, 2013-03-12;8(3):e58953.  2013-03-12
  6. Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade.
    Authors: Reddy RM, Yeow WS, Chua A, Nguyen DM, Baras A, Ziauddin MF, Shamimi-Noori SM, Maxhimer JB, Schrump DS
    Apoptosis, 2007-01-01;12(1):55-71.  2007-01-01
  7. Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling.
    Authors: Yamazaki T, Muramoto M, Oe T, Morikawa N, Okitsu O, Nagashima T, Nishimura S, Katayama Y, Kita Y
    Neuropharmacology, 2006-01-04;50(5):558-67.  2006-01-04
  8. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
    Authors: Su YT, Chang HL, Shyue SK, Hsu SL
    Biochem. Pharmacol., 2005-07-15;70(2):229-41.  2005-07-15
  9. Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo.
    Authors: Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ
    Cancer Lett., 2004-11-19;222(2):183-93.  2004-11-19
  10. Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway.
    Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
    Cardiovasc. Res., 2004-06-01;62(3):558-67.  2004-06-01
  11. IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
    Authors: Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, Chen WS, Yang WK
    J. Interferon Cytokine Res., 2004-04-01;24(4):231-43.  2004-04-01
  12. Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.
    Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
    Cardiovasc. Res., 2004-01-01;61(1):143-51.  2004-01-01
  13. Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways.
    Authors: Walford GA, Moussignac RL, Scribner AW, Loscalzo J, Leopold JA
    J. Biol. Chem., 2003-11-03;279(6):4425-32.  2003-11-03
  14. The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis.
    Authors: Panduri V, 107352, Weitzman SA, Chandel N, Kamp DW
    Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells, 2003-02-01;28(2):241-8.  2003-02-01
  15. Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells.
    Authors: Chen YN, 2019, Chen JC, Yin SC, Wang GS, Tsauer W, Hsu SF, Hsu SL
    7020, 2002-07-10;100(2):158-65.  2002-07-10
  16. Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs.
    Authors: Zhang Y, 107275, Chong E, Herman B
    Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung, 2002-06-01;37(6):777-89.  2002-06-01
  17. Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard.
    Authors: Becker R, Ritter A, Eichhorn U, Lips J, Bertram B, Wiessler M, Zdzienicka MZ, Kaina B
    Br. J. Cancer, 2002-01-07;86(1):130-5.  2002-01-07

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