Catalog Number: 3949
Chemical Name: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride
Biological Activity
Selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.
Technical Data
  • M.Wt:
    413.92
  • Formula:
    C21H19N3O2S.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    856702-40-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).
    Johnson et al.
    Psychopharmacology., 2005;179:271
  2. Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge.
    Fell et al.
    Neuropharmacology., 2010;58:632
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CBiPES hydrochloride include:

1 Citations: Showing 1 - 1

  1. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
    Authors: Yin Et al.
    J Neurosci 2014;34:79

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