CBiPES hydrochloride
Chemical Name: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride
Purity: ≥99%
Biological Activity
Selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).
Johnson et al.
Psychopharmacology., 2005;179:271 -
Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute KA challenge.
Fell et al.
Neuropharmacology., 2010;58:632
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Citation for CBiPES hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CBiPES hydrochloride include:
1 Citation: Showing 1 - 1
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Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
Authors: Yin Et al.
J Neurosci 2014;34:79
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