Selective positive allosteric modulator of the mGlu2
= 98.2 nM). Mimics the action of LY 379268
(Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo
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All Tocris products are intended for laboratory research use only.
Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).
Johnson et al.
Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge.
Fell et al.
The citations listed below are publications that use Tocris products. Selected citations for CBiPES hydrochloride include:
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