Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Biological ActivityLY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. LY379268 disodium salt also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia.
Bond et al.
Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo.
Bond et al.
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties.
Collado et al.
Citations for LY 379268
The citations listed below are publications that use Tocris products. Selected citations for LY 379268 include:
19 Citations: Showing 1 - 10
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
Nat Commun 2017;8(1):1967
mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.
Authors: Chandrasekaran Et al.
Ann Clin Transl Neurol 2017;4:844
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum.
The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
Authors: Carbonaro Et al.
J Neurosci 2015;232:275
The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation.
Authors: Erlandson Et al.
Psychopharmacology (Berl) 2015;10:e0132008
Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
Authors: Wang Et al.
PLoS One 2013;8:e61787
Group II metabotropic glutamate receptors modify N-MthD.-aspartate receptors via Src kinase.
Authors: Trepanier Et al.
Sci Rep 2013;3:926
Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury.
Authors: Hinzman Et al.
J Neurotrauma 2012;29:1197
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A-mGlu2) receptor heteromerization and its psychoactive behavioral function.
Authors: Moreno Et al.
Front Mol Neurosci 2012;287:44301
Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.
Authors: Vinkers Et al.
Psychopharmacology (Berl) 2012;219:897
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes.
Authors: Durand Et al.
PLoS One 2011;6:e22235
mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum.
Authors: Liberto Et al.
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring.
Authors: Moreno Et al.
J Biol Chem 2011;31:1863
The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.
Authors: Bellesi and Conti
Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses DA depletion-induced dendritic spine loss.
Authors: Garcia Et al.
Cereb Cortex 2010;20:2423
The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
Authors: Chen Et al.
Psychopharmacology (Berl) 2010;209:343
A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
Authors: Sekizawa Et al.
J Neurosci 2009;29:11807
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