Highly selective group II mGlu receptor agonist (EC50
values are 2.69 and 4.48 nM for hmGlu2
respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro
and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268
is also available (Cat. No. 3332).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from Eli Lilly and Company
LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia.
Bond et al.
Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo.
Bond et al.
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties.
Collado et al.
The citations listed below are publications that use Tocris products. Selected citations for LY 379268 include:
Showing Results 1 - 10 of 13