Catalog Number: 2453
Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Biological Activity
Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332).
Technical Data
  • M.Wt:
    187.15
  • Formula:
    C7H9NO5
  • Solubility:
    Soluble to 20 mM in water and to 100 mM in 1eq. NaOH
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    191471-52-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Eli Lilly and Company
Background References
  1. LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia.
    Bond et al.
    Neurosci.Lett., 1999;273:191
  2. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo.
    Bond et al.
    J.Pharmacol.Exp.Ther., 2000;294:800
  3. (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties.
    Collado et al.
    J.Med.Chem., 2002;45:3619
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 379268 include:

14 Citations: Showing 1 - 10
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  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
    Authors: Carbonaro Et al.
    J Neurosci 2015;232:275
  3. The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation.
    Authors: Erlandson Et al.
    Psychopharmacology (Berl) 2015;10:e0132008
  4. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    PLoS One 2013;8:e61787
  5. Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase.
    Authors: Trepanier Et al.
    Sci Rep 2013;3:926
  6. Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury.
    Authors: Hinzman Et al.
    J Neurotrauma 2012;29:1197
  7. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A-mGlu2) receptor heteromerization and its psychoactive behavioral function.
    Authors: Moreno Et al.
    Front Mol Neurosci 2012;287:44301
  8. Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.
    Authors: Vinkers Et al.
    Psychopharmacology (Berl) 2012;219:897
  9. Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes.
    Authors: Durand Et al.
    PLoS One 2011;6:e22235
  10. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring.
    Authors: Moreno Et al.
    J Biol Chem 2011;31:1863
  11. The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.
    Authors: Bellesi and Conti
    Neuropsychopharmacology 2010;35:1253
  12. Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss.
    Authors: Garcia Et al.
    Cereb Cortex 2010;20:2423
  13. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
    Authors: Chen Et al.
    Psychopharmacology (Berl) 2010;209:343
  14. A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
    Authors: Sekizawa Et al.
    J Neurosci 2009;29:11807
Expand to show all 14 Citations
Tocris Small Molecules
Description Application Cat# Citations Images  

LY 379268 disodium salt

5064  
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