Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Biological ActivityLY 379268 is a highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia.
Bond et al.
Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo.
Bond et al.
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties.
Collado et al.
Citations for LY 379268
The citations listed below are publications that use Tocris products. Selected citations for LY 379268 include:
19 Citations: Showing 1 - 10
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
Nat Commun 2017;8(1):1967
mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.
Authors: Chandrasekaran Et al.
Ann Clin Transl Neurol 2017;4:844
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Nat Chem Biol 2017;13(4):372
Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum.
The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice.
Authors: Carbonaro Et al.
J Neurosci 2015;232:275
The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation.
Authors: Erlandson Et al.
Psychopharmacology (Berl) 2015;10:e0132008
Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
Authors: Wang Et al.
PLoS One 2013;8:e61787
Group II metabotropic glutamate receptors modify N-MthD.-aspartate receptors via Src kinase.
Authors: Trepanier Et al.
Sci Rep 2013;3:926
Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury.
Authors: Hinzman Et al.
J Neurotrauma 2012;29:1197
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A-mGlu2) receptor heteromerization and its psychoactive behavioral function.
Authors: Moreno Et al.
Front Mol Neurosci 2012;287:44301
Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.
Authors: Vinkers Et al.
Psychopharmacology (Berl) 2012;219:897
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes.
Authors: Durand Et al.
PLoS One 2011;6:e22235
mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum.
Authors: Liberto Et al.
Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring.
Authors: Moreno Et al.
J Biol Chem 2011;31:1863
The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.
Authors: Bellesi and Conti
Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses DA depletion-induced dendritic spine loss.
Authors: Garcia Et al.
Cereb Cortex 2010;20:2423
The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.
Authors: Chen Et al.
Psychopharmacology (Berl) 2010;209:343
A novel postsynaptic group II metabotropic glutamate receptor role in modulating baroreceptor signal transmission.
Authors: Sekizawa Et al.
J Neurosci 2009;29:11807
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