CCF 642 (CAS 346640-08-2): R&D Systems
Catalog Number: 6063
Chemical Name: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
Biological Activity
Protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.
Technical Data
  • M.Wt:
    378.45
  • Formula:
    C15H10N2O4S3
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    346640-08-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma.
    Vatolin et al.
    Cancer Res., 2016;76:3340
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