Protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro
(submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.
Soluble to 20 mM in DMSO
Store at -20°C
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Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma.
Vatolin et al.
Cancer Res., 2016;76:3340