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CCF 642

Catalog #: 6063 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6063/10
6063/50
CCF 642 | CAS No. 346640-08-2 | Protein Disulphide Isomerase Inhibitors
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Description: Protein disulfide isomerase (PDI) inhibitor

Chemical Name: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone

Purity: ≥98%

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Biological Activity

CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.

Technical Data

M.Wt:
378.45
Formula:
C15H10N2O4S3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
346640-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma.
    Vatolin et al.
    Cancer Res., 2016;76:3340

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