Protein Disulphide Isomerase Inhibitors

Protein Disulfide Isomerase (PDI, EC 5.4.3.1) is a multifunctional redox protein which acts as a regulator of disulfide bond formation and rearrangement (isomerization). In doing so it functions as both an enzyme and as a molecular chaperone.

PDI, the first catalyst of protein folding to be characterized, is a member of the PDI family of proteins which are mainly localized to the endoplasmic reticulum (ER), are upregulated in response to ER stress and have an important role in protein ...