Catalog Number: 1549
Alternate Names: AHPN
Chemical Name: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Biological Activity
Synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.
Technical Data
  • M.Wt:
    398.5
  • Formula:
    C27H26O3
  • Solubility:
    Soluble to 20 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    125316-60-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis.
    Zhao and Spanjaard
    J.Biomed.Sci., 2003;10:44
  2. Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
    Wang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:18283
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CD 437 include:

2 Citations: Showing 1 - 2
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  1. Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells.
    Authors: Kelley
    PLoS One 2017;12(5):e0178116
  2. Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity.
    Authors: Brigger Et al.
    J Neurosci 2015;6:e1861

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