Chemical Name: (2R,3S)-3-[(4E,7E)-1-Oxo-4,7-nonadien-1-yl]-2-oxiranecarboxamide
Biological ActivityIrreversible fatty acid synthase inhibitor. Blocks proliferation of KRAS-driven lung cancer cells. Promotes apoptosis and inhibits necroptosis in cancer cells. Also inhibits protein palmitoylation and insulin uptake in rat adipocytes in vitro. Antibiotic.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma.
Gouw et al.
Very long chain fatty acids are functionally involved in necroptosis.
Parisi et al.
Cell Chem.Bio., 2017;24:1445
Inhibitory effects of cerulenin on protein palmitoylation and Ins internalization in rat adipocytes.
Jochen et al.
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