Catalog Number: 1082
Chemical Name: 1-(4'-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one
Biological Activity
Novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
    Chimirri et al.
    J.Med.Chem., 1997;40:1258
  2. Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats.
    De Sarro et al.
    Eur.J.Pharmacol., 1999;368:149
  3. Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats.
    De Sarro et al.
    Pharmacol.Biochem.Behav., 1999;63:621

The citations listed below are publications that use Tocris products. Selected citations for CFM-2 include:

Showing Results 1 - 2 of 2

  1. Melanoma brain colonization involves the emergence of a brain-adaptive phenotype.
    Authors: Nygaard Et al.
    Proc Natl Acad Sci U S A
  2. Glutamate antagonists limit tumor growth.
    Authors: Rzeski Et al.
    J Pharmacol Exp Ther
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