Catalog Number: 1409
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
Biological Activity
Potent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Centrally active upon oral administration in vivo.
Technical Data
  • M.Wt:
    237.19
  • Formula:
    C8H16NO5P
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    127910-32-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of competitive NMDA receptor antagonists on excitatory amino-acid-evoked currents in mouse spinal cord.
    D'Hooge et al.
    Fundam.Clin.Pharmacol., 1999;13:67
  2. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity.
    Fagg et al.
    Br.J.Pharmacol., 1990;99:791
  3. Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
    Loscher and Honack
    J.Pharmacol.Exp.Ther., 1991;256:432
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 39551 include:

2 Citations: Showing 1 - 2
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  1. Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal.
    Authors: Grieder Et al.
    Proc Natl Acad Sci U S A 2012;109:3101
  2. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking.
    Authors: Bäckström and Hyytiä
    Neuropsychopharmacology 2006;31:778

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