Chlormethiazole hydrochloride (CAS 6001-74-7): R&D Systems
Catalog Number: 0881
Chemical Name: 5-(2-Chloroethyl)-4-methylthiazole hydrochloride
Biological Activity
Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
Technical Data
  • M.Wt:
    198.11
  • Formula:
    C6H8ClNS.HCl
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    6001-74-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chloromethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by the administration of MDMA ('Ecstasy') to rats.
    Hewitt and Green
    Neuropharmacology, 1994;33:1589
  2. The protective action of chloromethiazole against ischaemia induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity.
    Cross et al.
    Br.J.Pharmacol., 1995;114:1625

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