CHM 1

Catalog # Availability Size / Price Qty
3868/10
3868/50
CHM 1 | CAS No. 154554-41-3 | Apoptosis Inducer Compounds
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Description: Potent antitumor agent; inducer of apoptosis

Chemical Name: 6-(2-Fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one

Purity: ≥99%

Product Details
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Biological Activity

Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.

Technical Data

M.Wt:
283.25
Formula:
C16H10FNO3
Solubility:
Soluble to 25 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
154554-41-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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