Apoptosis Inducer Compounds: Products

Antitumor antibiotic agent. Inhibits DNA topoisomerase II

Potent pro-apoptotic anticancer agent; activates caspase-3

DNA cross-linking antitumor agent

Alkylating agent; chemotherapeutic

DNA cross-linking antitumor agent

Inhibits RNA polymerase

DNA alkylator; antitumor and induces diabetes

DNA cross-linking antitumor agent

DNA-methylating antitumor agent

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

Purine analog; inhibits DNA synthesis

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

High affinity and selective activator of Bax

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

Hypoxia-activated DNA alkylating agent prodrug

Selectively induces cancer cell apoptosis

Potent fatty acid synthase inhibitor; proapoptotic

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

Induces abnormal nuclear aggregation of PKCι; proapoptotic

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

Cytostatic agent; exhibits DNA alkylating and purine analog properties

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

Potent and selective HDAC8 inhibitor

Suppressor of MDK expression; inhibits PI 3-K signaling

IAP and XIAP inhibitor; antitumor

Deoxyadenosine analog; pro-apoptotic

ULK inhibitor

Antibiotic; selectively induces apoptosis of CLL cells

Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

Pan-histone deacetylase inhibitor

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Potent and selective MEK inhibitor; orally bioavailable

Potent UNC-51-like kinase 1 (ULK1) agonist