Catalog Number: 2942
Alternate Names: PD 156707
Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]-2(5H)-furanone
Biological Activity
Highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration.
Technical Data
  • M.Wt:
    506.5
  • Formula:
    C28H26O9
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    162256-50-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.
    Doherty et al.
    J.Med.Chem., 1995;38:1259
  2. The effect of the endothelin ETA receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction.
    Jones et al.
    Eur.J.Pharmacol., 1999;374:367
  3. The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in ther perinatal lamb.
    Coe et al.
    J.Pharmacol.Exp.Ther., 2002;302:672

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