Chemical Name: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Biological ActivityClofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
Parker et al.
Cancer Res., 1991;51:2386
Discovery and development of clofarabine: a nucleoside analogue for treating cancer.
Bonate et al.
Nat.Rev.Drug Discov., 2006;5:855
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
Carson et al.
Citation for Clofarabine
The citations listed below are publications that use Tocris products. Selected citations for Clofarabine include:
1 Citation: Showing 1 - 1
Valproic acid synergistically enhances the cytotoxicity of clofar. in pediatric acute myeloid leukemia cells.
Authors: Xie Et al.
Pediatr Blood Cancer 2012;59:1245
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