Catalog Number: 2600
Chemical Name: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
Biological Activity
Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
Technical Data
  • M.Wt:
    303.68
  • Formula:
    C10H11ClFN5O3
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    123318-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
    Parker et al.
    Cancer Res., 1991;51:2386
  2. Discovery and development of clofarabine: a nucleoside analogue for treating cancer.
    Bonate et al.
    Nat.Rev.Drug Discov., 2006;5:855
  3. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
    Carson et al.
    Proc.Natl.Acad.Sci.USA, 1992;89:2970
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Clofarabine include:

1 Citations: Showing 1 - 1

  1. Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells.
    Authors: Xie Et al.
    Pediatr Blood Cancer 2012;59:1245

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