Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α
and potently inhibits ribonucleotide reductase (IC50
= 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
Parker et al.
Cancer Res., 1991;51:2386
Discovery and development of clofarabine: a nucleoside analogue for treating cancer.
Bonate et al.
Nat.Rev.Drug Discov., 2006;5:855
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
Carson et al.
The citations listed below are publications that use Tocris products. Selected citations for Clofarabine include:
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