Clofarabine

Catalog # Availability Size / Price Qty
2600/25
2600/5
Clofarabine | CAS No. 123318-82-1 | Kinase Substrates
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Description: Deoxycytidine kinase (dCK) substrate

Chemical Name: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

Technical Data

M.Wt:
303.68
Formula:
C10H11ClFN5O3
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
123318-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
    Parker et al.
    Cancer Res., 1991;51:2386
  2. Discovery and development of clofarabine: a nucleoside analogue for treating cancer.
    Bonate et al.
    Nat.Rev.Drug Discov., 2006;5:855
  3. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
    Carson et al.
    Proc.Natl.Acad.Sci.USA, 1992;89:2970

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Citation for Clofarabine

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