Chemical Name: N,N'-(1,4-Phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide
Biological ActivityPositive allosteric modulator of GluA2 receptors (EC50 values are 45.4 and 63.4 nM at GluA2i and GluA2o respectively, in a calcium influx screening assay). Binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Timm et al.
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VersaClone cDNA Plasmids
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