Positive allosteric modulator of GluR2 receptors (EC50
values are 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay). Binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges.
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Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Timm et al.