Catalog Number: 4373
Chemical Name: N,N'-(1,4-Phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide
Biological Activity
Positive allosteric modulator of GluR2 receptors (EC50 values are 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assay). Binds at the modulator binding pocket located at the interdimer interface and the clamshell hinges.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
    Timm et al.
    Mol.Pharmacol., 2011;80:267
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