p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo
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Pharmacological rescue of mutant p53 conformation and function.
Foster et al.
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.
Wischhusen et al.
CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73.
Demma et al.
The citations listed below are publications that use Tocris products. Selected citations for CP 31398 dihydrochloride include:
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