Catalog Number: 3023
Chemical Name: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride
Biological Activity
p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Pharmacological rescue of mutant p53 conformation and function.
    Foster et al.
    Science, 1999;286:2507
  2. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.
    Wischhusen et al.
    Oncogene, 2003;22:8233
  3. CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73.
    Demma et al.
    J.Biol.Chem., 2004;279:45887

The citations listed below are publications that use Tocris products. Selected citations for CP 31398 dihydrochloride include:

Showing Results 1 - 2 of 2

  1. A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion.
    Authors: Grugan Et al.
    Mol Cell Neurosci
  2. p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.
    Authors: Roh Et al.
    Oral Oncol
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