Chemical Name: 5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
Biological ActivityCP 316819 is a selective glycogen phosphorylase inhibitor [IC50 values are 0.017 and 0.034 μM against human skeletal muscle glycogen phosphorylase a (huSMGPa) and liver glycogen phosphorylase a (huLGPa) respectively]. Antihyperglycemic agent.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle.
Baker et al.
Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation site of the enzyme.
Freeman et al.
Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-ca
Suh et al.
Citations for CP 316819
The citations listed below are publications that use Tocris products. Selected citations for CP 316819 include:
2 Citations: Showing 1 - 2
Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma.
Authors: Jun Et al.
Nat Metab 2021;3:327-336
Energy substrates that fuel fast neuronal network oscillations.
Authors: Galow Et al.
J Exp Bot 2014;8:398
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