Catalog Number: 2893
Chemical Name: (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
Biological Activity
Potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.
Technical Data
  • M.Wt:
    412.57
  • Formula:
    C28H32N2O
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    132746-60-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. A potent nonpeptide antagonist of the substance P (NK1) receptor.
    Snider et al.
    Science, 1991;251:435
  2. Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury.
    Bang et al.
    J.Pharmacol.Exp.Ther., 2003;305:31
  3. The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation.
    Lembeck et al.
    Br.J.Pharmacol., 1992;105:527
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 96345 include:

1 Citations: Showing 1 - 1

  1. Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.
    Authors: Silva Et al.
    Br J Pharmacol 2015;172:924

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