CP 96345

Key Product Details

Product Description

CP 96345 is a potent and selective non-peptide NK₁ receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for CP 96345

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CP 96345

The following data is based on the product molecular weight 412.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.12 mL	60.60 mL	121.19 mL
1 mM	2.42 mL	12.12 mL	24.24 mL
2 mM	1.21 mL	6.06 mL	12.12 mL
10 mM	0.24 mL	1.21 mL	2.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Lembeck The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 1992 PMID: 1378337
• Bang Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 2003 PMID: 12649350
• Snider A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 1991 PMID: 1703323

Product Documents for CP 96345