Chemical Name: (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
Biological ActivityCP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A potent nonpeptide antagonist of the substance P (NK1) receptor.
Snider et al.
The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation.
Lembeck et al.
Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury.
Bang et al.
Citation for CP 96345
The citations listed below are publications that use Tocris products. Selected citations for CP 96345 include:
1 Citation: Showing 1 - 1
Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.
Authors: Silva Et al.
Br J Pharmacol 2015;172:924
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