Chemical Name: (RS)-α-Cyclopropyl-4-phosphonophenylglycine
Biological ActivityCPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). A much less potent antagonist at group I receptors in neonatal rat cortical slices (KB = 0.65 ± 0.07 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
Potent antagonists at L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate recpetors in neonatal rat spinal cord.
Jane et al.
Potent antagonists at the L-AP4- and (1S, 3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.
Jane et al.
The effects of (RS)-α-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist.
Toms et al.
α-Methyl-3-phosphonophenylglycine and α-cyclopropyl-4-phosphonophenylglycine are potent antagonists at mGluRs negatively coupled to adenylyl cyclase.
Kemp et al.
Br.J.Pharmacol., 1996;117:(in press)
Citations for CPPG
The citations listed below are publications that use Tocris products. Selected citations for CPPG include:
21 Citations: Showing 1 - 10
A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.
Authors: Hellmer Et al.
Physiol Rep 2018;6:e13885
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
Nat Commun 2017;8(1):2255
Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network.
Authors: Tassin Et al.
Front Neural Circuits 2016;10:31
Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.
Authors: Spampinato Et al.
Neurotox Res 2015;8:462
Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
Authors: Nieus Et al.
Front Cell Neurosci 2014;8:246
Examination of VLC-PUFA-deficient photoreceptor terminals.
Authors: Bennett Et al.
J Neurosci 2014;55:4063
Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.
Authors: Domin Et al.
Proc Natl Acad Sci U S A 2014;26:99
Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex.
Authors: De-May and Ali
J Neurophysiol 2013;109:216
Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
Authors: He Et al.
Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
Authors: Cassé Et al.
J Neurosci 2012;32:5186
The mode of retinal presynaptic inhibition switches with light intensity.
Authors: Ichinose and Lukasiewicz
J Neurosci 2012;32:4360
Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
Authors: Broadstock Et al.
Br J Pharmacol 2012;165:1034
CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
J Neurophysiol 2011;105:1051
RGS7 and -11 complexes accelerate the ON-bipolar cell light response.
Authors: Zhang Et al.
Invest Ophthalmol Vis Sci 2010;51:1121
Slow glycinergic transmission mediated by transmitter pooling.
Authors: Balakrishnan Et al.
Nat Neurosci 2009;12:286
Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
Authors: Rancillac Et al.
J Neurosci 2006;26:6997
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
Front Cell Neurosci 2005;25:5502
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Authors: Mathiesen Et al.
Br J Pharmacol 2003;138:1026
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
Authors: Nishi Et al.
Invest Ophthalmol Vis Sci 2003;100:1322
Neutrophil-derived glutamate regulates vascular endothelial barrier function.
Authors: Collard Et al.
J Biol Chem 2002;277:14801
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Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail - 600 umol/L
CPPG (5 microM) was used for pharmacological isolation of GABA-A receptor activity in nucleated membrane patches. Being added to perfusion solution, CPPG blocked contaminating receptor activity in a recorded response, thus revealing clear GABA-ergic single-channel openings. Figure: single-channel openings of GABA-A receptors in a membrane patch after application of CPPG.