CPPG

  ( 18 citations )    
Product Datasheet
Catalog Number:0972
Chemical Name:(RS)-α-Cyclopropyl-4-phosphonophenylglycine
Product Details
Citations (18)
Reviews
Biological Activity
Potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). A much less potent antagonist at group I receptors in neonatal rat cortical slices (KB = 0.65 ± 0.07 nM). Also available as part of the Group III mGlu Receptor Tocriset™.
Technical Data
  • M.Wt:
    271.21
  • Formula:
    C11H14NO5P
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    183364-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CPPG include:

18 Citations: Showing 1 - 10
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  1. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
    Authors: Dornier
    Nat Commun  2017;8(1):2255
  2. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.
    Authors: Spampinato Et al.
    Neurotox Res  2015;8:462
  3. Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
    Authors: Nieus Et al.
    Front Cell Neurosci  2014;8:246
  4. Examination of VLC-PUFA-deficient photoreceptor terminals.
    Authors: Bennett Et al.
    J Neurosci  2014;55:4063
  5. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.
    Authors: Domin Et al.
    Proc Natl Acad Sci U S A  2014;26:99
  6. Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex.
    Authors: De-May and Ali
    J Neurophysiol  2013;109:216
  7. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
    Authors: He Et al.
    Neuropsychopharmacology  2012;37:1338
  8. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
    Authors: Cassé Et al.
    J Neurosci  2012;32:5186
  9. The mode of retinal presynaptic inhibition switches with light intensity.
    Authors: Ichinose and Lukasiewicz
    J Neurosci  2012;32:4360
  10. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
    Authors: Broadstock Et al.
    Br J Pharmacol  2012;165:1034
  11. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol  2011;105:1051
  12. RGS7 and -11 complexes accelerate the ON-bipolar cell light response.
    Authors: Zhang Et al.
    Invest Ophthalmol Vis Sci  2010;51:1121
  13. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
    Authors: Rancillac Et al.
    J Neurosci  2006;26:6997
  14. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism.
    Authors: Jiang Et al.
    J Neurosci  2006;26:4318
  15. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    Front Cell Neurosci  2005;25:5502
  16. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
    Authors: Mathiesen Et al.
    Br J Pharmacol  2003;138:1026
  17. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Authors: Nishi Et al.
    Invest Ophthalmol Vis Sci  2003;100:1322
  18. Neutrophil-derived glutamate regulates vascular endothelial barrier function.
    Authors: Collard Et al.
    J Biol Chem  2002;277:14801
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