Catalog Number: 0993
Chemical Name: 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
Biological Activity
5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.
Technical Data
  • M.Wt:
    345.4
  • Formula:
    C16H21N3O2.½C4H4O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    69906-86-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.
    Engel et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1986;332:1
  2. Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol.
    Hoey et al.
    Br.J.Pharmacol., 1996;117:712
  3. Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding.
    Giles et al.
    Br.J.Pharmacol., 1996;117:1119
  4. Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum.
    Blue et al.
    Br.J.Pharmacol., 1989;96:246P
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cyanopindolol hemifumarate include:

1 Citations: Showing 1 - 1

  1. Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
    Authors: Kaya Et al.
    J Pharmacol Exp Ther 2009;329:350

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