Chemical Name: 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
Biological ActivityCyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.
Engel et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1986;332:1
Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol.
Hoey et al.
Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding.
Giles et al.
Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum.
Blue et al.
Citations for Cyanopindolol hemifumarate
The citations listed below are publications that use Tocris products. Selected citations for Cyanopindolol hemifumarate include:
4 Citations: Showing 1 - 4
Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
Authors: Gautam Et al.
Mol Cancer 2016;15:75
Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
Authors: Kaya Et al.
J Pharmacol Exp Ther 2009;329:350
ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta.
Authors: Brahmadevara Et al.
Br J Pharmacol 2004;142:781
Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327
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