Chemical Name: 17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
Biological ActivityCyprodime hydrochloride is a selective μ-opioid receptor antagonist (Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime.
Schmidhammer et al.
μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPγs binding assays.
Marki et al.
μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
Henry et al.
Citations for Cyprodime hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Cyprodime hydrochloride include:
2 Citations: Showing 1 - 2
The Bivalent Rewarding and Aversive properties of δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions.
Authors: Norris Et al.
Sci Rep 2019;9:9760
Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats.
Authors: Lee Et al.
J Neurosci 2012;2012:941685
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Intra-cranial microinfusions for behavioural testing.