Catalog Number: 4981
Chemical Name: 2,2'-Diaminodiethyl disulfide dihydrochloride
Biological Activity
Transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.
Technical Data
  • M.Wt:
    225.2
  • Formula:
    C4H12N2S2.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at RT
  • CAS No:
    56-17-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
    Borrell-Pages et al.
    J.Clin.Invest., 2006;116:1410
  2. Therapeutic effects of cystamine in a murine model of Huntington's disease.
    Dedeoglu et al.
    J.Neurosci., 2002;22:8942
  3. Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells.
    Mao et al.
    Eur.J.Neurosci., 2006;23:1701

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