Biological Activityd[Cha4]-AVP is a potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
(Modifications: X-1 = Mpr, X-4 = Cha, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
[1-Deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors.
Derick et al.
Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4.
Cheng et al.
Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8.
Pena et al.
Citation for d[Cha4]-AVP
The citations listed below are publications that use Tocris products. Selected citations for d[Cha4]-AVP include:
1 Citation: Showing 1 - 1
IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
Authors: Perígolo-Vicente Et al.
Biochem Biophys Res Commun 2014;449:477
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