D-CPP-ene (CAS 117414-74-1): R&D Systems
Catalog Number: 1265
Alternate Names: Midafotel, SDZ EAA 494
Chemical Name: D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
Biological Activity
Potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801.
    Lowe et al.
    Neurosci.Lett., 1990;113:315
  2. Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats.
    Potschka et al.
    Eur.J.Pharmacol., 1999;374:175
  3. Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene).
    Aebischer et al.
    Helv.Chim.Acta, 1989;72:1043

The citations listed below are publications that use Tocris products. Selected citations for D-CPP-ene include:

1 Citations: Showing 1 - 1

  1. NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation.
    Authors: Campos and Ritter
    Oncogene 2015;308:R1

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