Catalog Number: 1171
Alternate Names: DAGO
Chemical Name: [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin
Biological Activity
Highly selective peptide agonist for the μ opioid receptor.
Technical Data
  • M.Wt:
    513.7
  • Formula:
    C26H35N5O6
  • Sequence:
    YAGFG

    (Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    78123-71-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Studies in vitro with ICI 174,864, [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO).
    Hirning et al.
    Neuropeptides, 1985;5:383
  2. Opioid receptors (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla.
    Fang et al.
    Brain Res., 1989;501:116
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DAMGO include:

21 Citations: Showing 1 - 10
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  1. Characterization of structurally novel G protein biased CB1 agonists: implications for drug development.
    Authors: Ford
    Pharmacol Res 2017;125:161
  2. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports 2016;6:37834
  3. Microglia disrupt mesolimbic reward circuitry in chronic pain.
    Authors: Taylor Et al.
    Br J Pharmacol 2015;35:8442
  4. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci 2015;22:79
  5. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    PLoS One 2015;19:2587
  6. Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
    Authors: Ong Et al.
    J Neurosci 2015;172:615
  7. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.
    Authors: Beaudry Et al.
    Invest Ophthalmol Vis Sci 2015;172:2573
  8. Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model.
    Authors: Bai Et al.
    J Neurosci 2015;10:e0122924
  9. Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord.
    Authors: Brewer Et al.
    Front Neural Circuits 2014;8:62
  10. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain 2013;6:42
  11. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem 2013;288:36703
  12. Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.
    Authors: Rajasekaran Et al.
    Toxicol Appl Pharmacol 2013;269:100
  13. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
    Authors: Kharmate Et al.
    Cancer Cell Int 2013;13:93
  14. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.
    Authors: Reyes Et al.
    Exp Neurol 2012;233:205
  15. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
    Authors: Lee Et al.
    Br J Pharmacol 2011;36:2008
  16. Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.
    Authors: Krook-Magnuson Et al.
    J Neurosci 2011;31:14861
  17. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Neurochem Res 2011;31:13068
  18. Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy.
    Authors: Lorier Et al.
    PLoS One 2010;5:e8766
  19. The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy.
    Authors: Hull Et al.
    J Pharmacol Exp Ther 2010;332:1127
  20. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
    Authors: Garzón Et al.
    Mol Pain 2009;5:11
  21. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
    Authors: Kokkola Et al.
    BMC Cell Biol 2005;6:21
Expand to show all 21 Citations
Average Rating: 5 (Based on 1 review)

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