DAMGO

  ( 27 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1171
Alternate Names:DAGO
Chemical Name:[D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin
Product Details
Citations (27)
Supplemental Products
Reviews
Biological Activity
Highly selective peptide agonist for the μ opioid receptor.
Technical Data
  • M.Wt:
    513.7
  • Formula:
    C26H35N5O6
  • Sequence:
    YAGFG

    (Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    78123-71-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DAMGO include:

27 Citations: Showing 1 - 10
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  1. δ-subunit containing GABAA receptors modulate respiratory networks.
    Authors: Montandon
    Sci Rep  2017;7(1):18105
  2. Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.
    Authors: Ye
    Neuroscience  2017;363:50
  3. Characterization of structurally novel G protein biased CB1 agonists: implications for drug development.
    Authors: Ford
    Pharmacol Res  2017;125:161
  4. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports  2016;6:37834
  5. Microglia disrupt mesolimbic reward circuitry in chronic pain.
    Authors: Taylor Et al.
    Br J Pharmacol  2015;35:8442
  6. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci  2015;22:79
  7. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    PLoS One  2015;19:2587
  8. Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
    Authors: Ong Et al.
    J Neurosci  2015;172:615
  9. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.
    Authors: Beaudry Et al.
    Invest Ophthalmol Vis Sci  2015;172:2573
  10. Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model.
    Authors: Bai Et al.
    J Neurosci  2015;10:e0122924
  11. Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord.
    Authors: Brewer Et al.
    Front Neural Circuits  2014;8:62
  12. μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
    Authors: Chen Et al.
    Neuroscience  2014;267:67
  13. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  14. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem  2013;288:36703
  15. Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.
    Authors: Rajasekaran Et al.
    Toxicol Appl Pharmacol  2013;269:100
  16. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
    Authors: Kharmate Et al.
    Cancer Cell Int  2013;13:93
  17. Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.
    Authors: Gruol Et al.
    Alcohol Clin Exp Res  2012;36:443
  18. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.
    Authors: Reyes Et al.
    Exp Neurol  2012;233:205
  19. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  20. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
    Authors: Lee Et al.
    Br J Pharmacol  2011;36:2008
  21. Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.
    Authors: Krook-Magnuson Et al.
    J Neurosci  2011;31:14861
  22. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Neurochem Res  2011;31:13068
  23. Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy.
    Authors: Lorier Et al.
    PLoS One  2010;5:e8766
  24. The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy.
    Authors: Hull Et al.
    J Pharmacol Exp Ther  2010;332:1127
  25. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
    Authors: Garzón Et al.
    Mol Pain  2009;5:11
  26. Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
    Authors: Maione Et al.
    J Neurophysiol  2009;101:2411
  27. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
    Authors: Kokkola Et al.
    BMC Cell Biol  2005;6:21
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