Chemical Name: [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin
Biological ActivityDAMGO is a highly selective peptide agonist for the μ opioid receptor.
(Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Opioid receptors (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla.
Fang et al.
Brain Res., 1989;501:116
Studies in vitro with ICI 174,864, [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO).
Hirning et al.
Citations for DAMGO
The citations listed below are publications that use Tocris products. Selected citations for DAMGO include:
37 Citations: Showing 1 - 10
A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
Authors: Nam Et al.
Cell Rep 2019;28:1154
Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
Authors: Nasrallah Et al.
Cell Rep 2019;27:86
Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
Authors: Dai Et al.
Exp Mol Med 2018;50:148
sMu opioid receptor agonist DAMGO produces place conditioning, abstinence-induced withdrawal, and naltrexone-dependent locomotor activation in planarians.
Authors: Dziedowiec Et al.
Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors.
Authors: Bao Et al.
Mol Pain 2018;14:1744806918769490
δ-subunit containing GABAA receptors modulate respiratory networks.
Sci Rep 2017;7(1):18105
Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.
Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
Authors: Schmid Et al.
Characterization of structurally novel G protein biased CB1 agonists: implications for drug development.
Pharmacol Res 2017;125:161
Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
Authors: Mamaligas Et al.
Scientific Reports 2016;6:37834
Microglia disrupt mesolimbic reward circuitry in chronic pain.
Authors: Taylor Et al.
Br J Pharmacol 2015;35:8442
Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
Authors: Liu Et al.
J Biomed Sci 2015;22:79
Bupren.-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
Authors: Wang Et al.
PLoS One 2015;19:2587
Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking.
Authors: Ong Et al.
J Neurosci 2015;172:615
Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.
Authors: Beaudry Et al.
Invest Ophthalmol Vis Sci 2015;172:2573
Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model.
Authors: Bai Et al.
J Neurosci 2015;10:e0122924
DA D3 receptor dysfunction prevents anti-nociceptive effects of mor. in the spinal cord.
Authors: Brewer Et al.
Front Neural Circuits 2014;8:62
μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
Authors: Chen Et al.
HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
Authors: Vicente-Sánchez Et al.
Mol Brain 2013;6:42
Development of functionally selective, small molecule agonists at kappa opioid receptors.
Authors: Zhou Et al.
J Biol Chem 2013;288:36703
Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.
Authors: Rajasekaran Et al.
Toxicol Appl Pharmacol 2013;269:100
Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
Authors: Morse Et al.
BMC Pharmacol Toxicol 2013;14:17
Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
Authors: Kharmate Et al.
Cancer Cell Int 2013;13:93
Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.
Authors: Gruol Et al.
Alcohol Clin Exp Res 2012;36:443
Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.
Authors: Reyes Et al.
Exp Neurol 2012;233:205
Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
Authors: Morse Et al.
PLoS One 2011;6:e25643
Differential pharmacological actions of meth. and Bupren. in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
Authors: Lee Et al.
Br J Pharmacol 2011;36:2008
Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.
Authors: Krook-Magnuson Et al.
J Neurosci 2011;31:14861
Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
Authors: Beaudry Et al.
Neurochem Res 2011;31:13068
Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy.
Authors: Lorier Et al.
PLoS One 2010;5:e8766
The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy.
Authors: Hull Et al.
J Pharmacol Exp Ther 2010;332:1127
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.
Authors: Nassirpour Et al.
J Neurosci 2010;30:13419
Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.
Authors: Wang Et al.
Proc Natl Acad Sci U S A 2010;107:13117
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor.
Authors: Garzón Et al.
Mol Pain 2009;5:11
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Authors: Maione Et al.
J Neurophysiol 2009;101:2411
S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
Authors: Kokkola Et al.
BMC Cell Biol 2005;6:21
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Texting exercise presser reflex and how damgo affected contraction and blood pressure