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Description: Selective μ agonist
Alternative Names: DAGO

Chemical Name: [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin

Purity: ≥95%

Product Details
Citations (37)
Supplemental Products
Reviews (1)

Biological Activity

DAMGO is a highly selective peptide agonist for the μ opioid receptor.

Technical Data


(Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)

Soluble to 2 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for DAMGO

The citations listed below are publications that use Tocris products. Selected citations for DAMGO include:

37 Citations: Showing 1 - 10

  1. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
    Authors: Akoume Et al.
    Sci Rep  2019;9:10074
  2. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
    Authors: Nam Et al.
    Cell Rep  2019;28:1154
  3. Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
    Authors: Nasrallah Et al.
    Cell Rep  2019;27:86
  4. Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
    Authors: Dai Et al.
    Exp Mol Med  2018;50:148
  5. sMu opioid receptor agonist DAMGO produces place conditioning, abstinence-induced withdrawal, and naltrexone-dependent locomotor activation in planarians.
    Authors: Dziedowiec Et al.
    Neuroscience  2018;386:214
  6. Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors.
    Authors: Bao Et al.
    Mol Pain  2018;14:1744806918769490
  7. δ-subunit containing GABAA receptors modulate respiratory networks.
    Authors: Montandon
    Sci Rep  2017;7(1):18105
  8. Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice.
    Authors: Ye
    Neuroscience  2017;363:50
  9. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
    Authors: Schmid Et al.
    Cell  2017;171:1165
  10. Characterization of structurally novel G protein biased CB1 agonists: implications for drug development.
    Authors: Ford
    Pharmacol Res  2017;125:161
  11. Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports  2016;6:37834
  12. Microglia disrupt mesolimbic reward circuitry in chronic pain.
    Authors: Taylor Et al.
    Br J Pharmacol  2015;35:8442
  13. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci  2015;22:79
  14. Bupren.-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    PLoS One  2015;19:2587
  15. Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking.
    Authors: Ong Et al.
    J Neurosci  2015;172:615
  16. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.
    Authors: Beaudry Et al.
    Invest Ophthalmol Vis Sci  2015;172:2573
  17. Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model.
    Authors: Bai Et al.
    J Neurosci  2015;10:e0122924
  18. DA D3 receptor dysfunction prevents anti-nociceptive effects of mor. in the spinal cord.
    Authors: Brewer Et al.
    Front Neural Circuits  2014;8:62
  19. μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
    Authors: Chen Et al.
    Neuroscience  2014;267:67
  20. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  21. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem  2013;288:36703
  22. Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.
    Authors: Rajasekaran Et al.
    Toxicol Appl Pharmacol  2013;269:100
  23. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
    Authors: Morse Et al.
    BMC Pharmacol Toxicol  2013;14:17
  24. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
    Authors: Kharmate Et al.
    Cancer Cell Int  2013;13:93
  25. Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.
    Authors: Gruol Et al.
    Alcohol Clin Exp Res  2012;36:443
  26. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.
    Authors: Reyes Et al.
    Exp Neurol  2012;233:205
  27. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  28. Differential pharmacological actions of meth. and Bupren. in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
    Authors: Lee Et al.
    Br J Pharmacol  2011;36:2008
  29. Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.
    Authors: Krook-Magnuson Et al.
    J Neurosci  2011;31:14861
  30. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Neurochem Res  2011;31:13068
  31. Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy.
    Authors: Lorier Et al.
    PLoS One  2010;5:e8766
  32. The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy.
    Authors: Hull Et al.
    J Pharmacol Exp Ther  2010;332:1127
  33. Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.
    Authors: Nassirpour Et al.
    J Neurosci  2010;30:13419
  34. Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2010;107:13117
  35. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor.
    Authors: Garzón Et al.
    Mol Pain  2009;5:11
  36. Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
    Authors: Maione Et al.
    J Neurophysiol  2009;101:2411
  37. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
    Authors: Kokkola Et al.
    BMC Cell Biol  2005;6:21


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Texting exercise presser reflex and how damgo affected contraction and blood pressure

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