Catalog Number: 1171
Alternate Names: DAGO
Chemical Name: [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin
Biological Activity
Highly selective peptide agonist for the μ opioid receptor.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Studies in vitro with ICI 174,864, [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO).
    Hirning et al.
    Neuropeptides, 1985;5:383
  2. Opioid receptors (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla.
    Fang et al.
    Brain Res., 1989;501:116

The citations listed below are publications that use Tocris products. Selected citations for DAMGO include:

Showing Results 1 - 10 of 19

  1. Microglia disrupt mesolimbic reward circuitry in chronic pain.
    Authors: Taylor Et al.
    Br J Pharmacol
  2. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci
  3. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    PLoS One
  4. Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
    Authors: Ong Et al.
    J Neurosci
  5. Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.
    Authors: Beaudry Et al.
    Invest Ophthalmol Vis Sci
  6. Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model.
    Authors: Bai Et al.
    J Neurosci
  7. Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord.
    Authors: Brewer Et al.
    Front Neural Circuits
  8. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain
  9. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Authors: Zhou Et al.
    J Biol Chem
  10. Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.
    Authors: Rajasekaran Et al.
    Toxicol Appl Pharmacol
  11. Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
    Authors: Kharmate Et al.
    Cancer Cell Int
  12. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons.
    Authors: Reyes Et al.
    Exp Neurol
  13. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
    Authors: Lee Et al.
    Br J Pharmacol
  14. Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation.
    Authors: Krook-Magnuson Et al.
    J Neurosci
  15. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Neurochem Res
  16. Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy.
    Authors: Lorier Et al.
    PLoS One
  17. The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy.
    Authors: Hull Et al.
    J Pharmacol Exp Ther
  18. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
    Authors: Garzón Et al.
    Mol Pain
  19. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
    Authors: Kokkola Et al.
    BMC Cell Biol
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