Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioic acid
Biological ActivityHistone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
Rose et al.
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