Histone demethylase KDM2/7 subfamily inhibitor (IC50
values are 0.55, 1.5 and 2.1 μ
M for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50
> 100 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
Rose et al.