Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioic acid
Biological ActivityDaminozide is a histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
Rose et al.
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