DAPTA

Name: DAPTA
Brand: Tocris Bioscience
SKU: 2423

Tocris Bioscience | Catalog # 2423

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Citations (19)

Product Documents

Chemokine receptor 5 (CCR5) antagonist

Discontinued Product

2423 has been discontinued. View all Chemokine Receptor Antagonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Chemokine receptor 5 (CCR5) antagonist

Alternative Names

D-Ala-peptide T-amide

View all Chemokine Receptor Antagonists »

Product Description

DAPTA is a chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Product Specifications for DAPTA

Molecular Weight

856.89

Formula

C₃₅H₅₆N₁₀O₁₅

Storage

Desiccate at -20°C

CAS Number

106362-34-9

PubChem ID

184644

InChI Key

AKWRNBWMGFUAMF-ZESMOPTKSA-N

SMILES

[H]N[C@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Rosi Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 2005 PMID: 15979806
Polianova Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 2005 PMID: 16002156
Ruff Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 2003 PMID: 15043212

Product Documents for DAPTA

Certificate of Analysis

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Download SDS

Product Specific Notices for DAPTA

For research use only

Citations for DAPTA

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