Catalog Number: 5774
Chemical Name: N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
Biological Activity
ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without effecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes.
    Herrero et al.
    Cancer Cell, 2015;28:170
  2. Targeting RAS-mutant cancers: is ERK the key?
    Ryan et al.
    Trends Cancer, 2015;1:183
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