DEL 22379

Key Product Details

Product Description

DEL 22379 is an ERK dimerization inhibitor (IC₅₀ ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.

Product Specifications for DEL 22379

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DEL 22379

The following data is based on the product molecular weight 444.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.50 mL	22.50 mL	44.99 mL
2.5 mM	0.90 mL	4.50 mL	9.00 mL
5 mM	0.45 mL	2.25 mL	4.50 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ryan Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 2015 PMID: 26858988
• Herrero Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 2015 PMID: 26267534

Product Documents for DEL 22379