ERK Inhibitors: Products

ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation.

ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation.

"ERK Inhibitors" has 8 results in Products.
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FR 180204

Selective ERK inhibitor


Dual-kinase inhibitor; inhibits CK2 and ERK8

XMD 8-92

ERK5/BMK1 inhibitor; also BRD4 inhibitor


Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal


Potent and selective ERK2 inhibitor


Potent and selective ERK5 inhibitor

DEL 22379

ERK dimerization inhibitor

AX 15836

Potent and selective ERK5 inhibitor
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