Novel allosteric potentiator of the metabotropic glutamate receptor mGlu5
. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu5
without any effect at other mGlu subtypes (EC50
for potentiation = 2 - 5.3 μ
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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
O'Brien et al.
Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.
Zhang et al.
DFB, an allosteric potentiator of mGluR5
Williams et al.
4th International Meeting on Metabotropic Glutamat, 2002;