DFB
Chemical Name: [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde
Purity: ≥99%
Biological Activity
DFB is a novel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu5 without any effect at other mGlu subtypes (EC50 for potentiation = 2 - 5.3 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
O'Brien et al.
Mol.Pharmacol., 2003;64:731 -
Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.
Zhang et al.
J.Pharmacol.Exp.Ther., 2005;315:1212 -
DFB, an allosteric potentiator of mGluR5
Williams et al.
4th International Meeting on Metabotropic Glutamat, 2002;
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for DFB
The citations listed below are publications that use Tocris products. Selected citations for DFB include:
1 Citation: Showing 1 - 1
-
mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.
Authors: Chen Et al.
J Biomed Sci 2011;18:19
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for DFB
There are currently no reviews for this product. Be the first to review DFB and earn rewards!
Have you used DFB?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
