DFB

Key Product Details

Product Description

DFB is a novel allosteric potentiator of the metabotropic glutamate receptor mGlu₅. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu₅ without any effect at other mGlu subtypes (EC₅₀ for potentiation = 2 - 5.3 μM).

Product Specifications for DFB

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DFB

The following data is based on the product molecular weight 244.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.19 mL	40.94 mL	81.89 mL
2.5 mM	1.64 mL	8.19 mL	16.38 mL
5 mM	0.82 mL	4.09 mL	8.19 mL
25 mM	0.16 mL	0.82 mL	1.64 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Zhang Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J.Pharmacol.Exp.Ther. 2005 PMID: 16135701
• Williams DFB, an allosteric potentiator of mGluR5 4th International Meeting on Metabotropic Glutamat
• O'Brien A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 2003 PMID: 12920211

Product Documents for DFB