Catalog Number: 1625
Alternate Names: 3,3'-Difluorobenzaldazine
Chemical Name: [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde
Biological Activity
Novel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Devoid of agonist activity itself, but potentiates (3 - 6-fold) the action of agonists at mGlu5 without any effect at other mGlu subtypes (EC50 for potentiation = 2 - 5.3 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
    O'Brien et al.
    Mol.Pharmacol., 2003;64:731
  2. Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.
    Zhang et al.
    J.Pharmacol.Exp.Ther., 2005;315:1212
  3. DFB, an allosteric potentiator of mGluR5
    Williams et al.
    4th International Meeting on Metabotropic Glutamat, 2002;

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