Catalog Number: 0125
Chemical Name: DL-2-Amino-3-phosphonopropionic acid
Biological Activity
Competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
    Evans et al.
    Br.J.Pharmacol., 1982;75:65
  2. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase.
    Hawkinson et al.
    Eur.J.Pharmacol., 1996;307:219
  3. L-2-Amino-3-phosphonopropionic acid completely antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes.
    Saugstad et al.
    Eur.J.Pharmacol., 1995;289:395

The citations listed below are publications that use Tocris products. Selected citations for DL-AP3 include:

Showing Results 1 - 1 of 1

  1. PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
    Authors: Vance Et al.
    J Neurosci
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