Catalog Number: 3083
Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Biological Activity
Benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
Technical Data
  • M.Wt:
    350.8
  • Formula:
    C17H18N2O4.HCl
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1215833-62-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. DMCM: a potent convusive benzodiazepine receptor ligand.
    Petersen
    Eur.J.Pharmacol., 1983;94:117
  2. Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
    Conto et al.
    Pharmacol.Biochem.Behav., 2005;82:417
  3. Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats.
    Sieve et al.
    Psychopharmacol., 2001;153:180
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DMCM hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice
    Authors: Alia Et al.
    Scientific Reports 2016;6:37823
  2. Synaptic GABAA receptor clustering without the γ2 subunit.
    Authors: Kerti-Szigeti Et al.
    J Virol 2014;34:10219
  3. GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.
    Authors: Nguyen Et al.
    J Neurosci 2013;1527:131

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