Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Biological ActivityBenzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
DMCM: a potent convusive benzodiazepine receptor ligand.
Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
Conto et al.
Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats.
Sieve et al.
Citations for DMCM hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DMCM hydrochloride include:
3 Citations: Showing 1 - 3
Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice
Authors: Alia Et al.
Scientific Reports 2016;6:37823
Synaptic GABAA receptor clustering without the γ2 subunit.
Authors: Kerti-Szigeti Et al.
J Virol 2014;34:10219
GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.
Authors: Nguyen Et al.
J Neurosci 2013;1527:131
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