Catalog Number: 3083
Chemical Name: 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Biological Activity
Benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. DMCM: a potent convusive benzodiazepine receptor ligand.
    Eur.J.Pharmacol., 1983;94:117
  2. Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
    Conto et al.
    Pharmacol.Biochem.Behav., 2005;82:417
  3. Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats.
    Sieve et al.
    Psychopharmacol., 2001;153:180

The citations listed below are publications that use Tocris products. Selected citations for DMCM hydrochloride include:

Showing Results 1 - 2 of 2

  1. Synaptic GABAA receptor clustering without the γ2 subunit.
    Authors: Kerti-Szigeti Et al.
    J Virol
  2. GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.
    Authors: Nguyen Et al.
    J Neurosci
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information