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DMF

4512 1 Review Datasheet / COA / SDS
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4512/50
DMF | CAS No. 624-49-7 | Additional Antioxidant Compounds
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Description: Nrf2 pathway activator; neuroprotective
Alternative Names: Dimethyl fumarate

Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester

Purity: ≥99%

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Biological Activity

DMF is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.

Technical Data

M.Wt:
144.13
Formula:
C6H8O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
624-49-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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MMF

4511
1 Citations
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Activation of nrf2 in mouse macrophages
By Anonymous on 09/24/2019
Application: Species: Mouse

used at 10um in mouse macrophages to activate NRF2

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