Catalog Number: 4512
Alternate Names: Dimethyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester
Biological Activity
Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.
Technical Data
  • M.Wt:
    144.13
  • Formula:
    C6H8O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    624-49-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.
    Linker et al.
    Brain, 2011;134:678
  2. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway.
    Scannevin et al.
    J.Pharmacol.Exp.Ther., 2012;341:274
Tocris Small Molecules
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MMF

4511  
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