DMF
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Description: Nrf2 pathway activator; neuroprotective
Alternative Names: Dimethyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1,4-dimethyl ester
Purity: ≥99%
Biological Activity
Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.Technical Data
M.Wt:
144.13
Formula:
C6H8O4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
624-49-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway.
Scannevin et al.
J.Pharmacol.Exp.Ther., 2012;341:274 -
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.
Linker et al.
Brain, 2011;134:678
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Activation of nrf2 in mouse macrophages
By Anonymous
on 09/24/2019
Application:
Species:
Mouse
used at 10um in mouse macrophages to activate NRF2
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