MMF

Key Product Details

Product Description

MMF is a nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).

Product Specifications for MMF

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MMF

The following data is based on the product molecular weight 130.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	7.69 mL	38.43 mL	76.86 mL
5 mM	1.54 mL	7.69 mL	15.37 mL
10 mM	0.77 mL	3.84 mL	7.69 mL
50 mM	0.15 mL	0.77 mL	1.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sciacovelli Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Nature 2016 PMID: 27580029
• Tang The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist. Biochem.Biophys.Res.Commun. 2008 PMID: 18722346
• Scannevin Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway. J.Pharmacol.Exp.Ther. 2012 PMID: 22267202
• Hanson Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J.Clin.Invest. 2010 PMID: 20664170
• Rao & Mishra Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J.Ethnopharmacol. 1998 PMID: 9613834

Product Documents for MMF