Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Biological ActivityNuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Rao & Mishra
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
Scannevin et al.
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
Hanson et al.
The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist.
Tang et al.
Citation for MMF
The citations listed below are publications that use Tocris products. Selected citations for MMF include:
1 Citation: Showing 1 - 1
Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
Authors: Cheng Et al.
Cell Rep. 2020;
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