Catalog Number: 4511
Alternate Names: mono-Methyl fumarate
Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Biological Activity
Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
    Rao & Mishra
    J.Ethnopharmacol., 1998;60:207
  2. Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
    Scannevin et al.
    J.Pharmacol.Exp.Ther., 2012;341:274
  3. Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
    Hanson et al.
    J.Clin.Invest., 2010;120:2910
  4. The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist.
    Tang et al.
    Biochem.Biophys.Res.Commun., 2008;375:562
  5. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
    Sciacovelli et al.
    Nature, 2016;537:544
Tocris Small Molecules
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