Chemical Name: 2(E)-Butenedioic acid 1-methyl ester
Biological ActivityNuclear factor (erythroid-derived-2)-like 2 (Nrf2) pathway activator. Also exhibits agonist activity at GPR109A. Primary metabolite of DMF (Cat. No. 4512).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Rao & Mishra
Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
Scannevin et al.
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
Hanson et al.
The psoriasis durg monomethylfumarate is a potent nicotinic receptor agonist.
Tang et al.
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