channel blocker and acetylcholine release stimulator. Potently enhances K+
H]-ACh release from rat hippocampal slices (EC50
= 700 nM), and also increases release of dopamine and glutamate (EC50
values are 0.25 and 0.22 μ
M, respectively). Orally active in vivo
; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine
(Cat. No. 1999) both in vitro
and in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek et al.
2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action.
Earl et al.