DMP 543

Catalog # Availability Size / Price Qty
2330/10
2330/50
Two-P Potassium Channels Blockers Small Molecule
1 Image
Description: Potent, orally active ACh release enhancer

Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K+ channel blocker.

Technical Data

M.Wt:
412.44
Formula:
C26H18F2N2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
160588-45-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for DMP 543

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