Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Biological ActivityAcetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K+ channel blocker.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek et al.
2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action.
Earl et al.
Citation for DMP 543
The citations listed below are publications that use Tocris products. Selected citations for DMP 543 include:
1 Citation: Showing 1 - 1
KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.
Authors: Ipavec Et al.
Pharmacol Res 2011;64:397
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for DMP 543
There are currently no reviews for this product. Be the first to review DMP 543 and earn rewards!
Have you used DMP 543?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image