Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Biological ActivityDMP 543 is an acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K+ channel blocker.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek et al.
2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action.
Earl et al.
Citation for DMP 543
The citations listed below are publications that use Tocris products. Selected citations for DMP 543 include:
1 Citation: Showing 1 - 1
KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.
Authors: Ipavec Et al.
Pharmacol Res 2011;64:397
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