Blocker of KV
7 (KCNQ) voltage-gated potassium channels; blocks KV
7.1+7.3 (KCNQ2+3) / M-currents (IC50
= 4 - 7 μ
M) and KV
7.1 (KCNQ1) homomeric channels (IC50
= 8.9 μ
M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo
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All Tocris products are intended for laboratory research use only.
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek et al.
Selectivity of linopirdine (DuP 966), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.
Schnee and Brown
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
Wang et al.
The citations listed below are publications that use Tocris products. Selected citations for Linopirdine dihydrochloride include:
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