Linopirdine dihydrochloride

  ( 10 citations )    
Product Datasheet
Catalog Number:1999
Alternate Names:DuP 996
Chemical Name:1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
Product Details
Citations (10)
Reviews
Biological Activity
Blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.
Technical Data
  • M.Wt:
    464.39
  • Formula:
    C26H21N3O.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    113168-57-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Linopirdine dihydrochloride include:

10 Citations: Showing 1 - 10
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  1. XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits.
    Authors: Greene Et al.
    J.Pharmacol.Exp.Ther.  2017;362:177
  2. Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss.
    Authors: Carrott Et al.
    J Pharmacol Exp Ther  2016;36:222
  3. Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
    Authors: Ghezzi Et al.
    Neuroscience  2016;340:62
  4. Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea.
    Authors: Zampini Et al.
    PLoS One  2014;9:e113750
  5. Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
    Authors: Lee Et al.
    Int J Mol Sci  2014;15:977
  6. Burst activity and ultrafast activation kinetics of CaV1.3 Ca2+ channels support presynaptic activity in adult gerbil hair cell ribbon synapses.
    Authors: Zampini Et al.
    Front Cell Neurosci  2013;591:3811
  7. Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex.
    Authors: Gigout Et al.
    BMC Neurosci  2012;13:42
  8. KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle.
    Authors: Joshi Et al.
    J Physiol  2009;329:368
  9. p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents.
    Authors: Luther and Birren
    J Neurosci  2009;29:5411
  10. KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of Cajal from the guinea pig bladder.
    Authors: Anderson Et al.
    J.Urol  2009;182:330

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