Blocker of K
7 (KCNQ) voltage-gated potassium channels; blocks K
7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC
= 4 - 7
M) and K
7.1 (KCNQ1) homomeric channels (IC
M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration
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All Tocris products are intended for laboratory research use only.
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine.
Zaczek et al.
Selectivity of linopirdine (DuP 966), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.
Schnee and Brown
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
Wang et al.
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