Linopirdine dihydrochloride

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Linopirdine dihydrochloride | CAS No. 113168-57-3 | Voltage-gated Potassium Channel Blockers
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Description: KV7 (KCNQ) channel blocker
Alternative Names: DuP 996

Chemical Name: 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride

Purity: ≥99%

Product Details
Citations (12)

Biological Activity

Linopirdine dihydrochloride is a blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Linopirdine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Linopirdine dihydrochloride include:

12 Citations: Showing 1 - 10

  1. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation.
    Authors: Lecrux Et al.
    J Neurosci  2017;37:1518
  2. XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits.
    Authors: Greene Et al.
    J.Pharmacol.Exp.Ther.  2017;362:177
  3. Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss.
    Authors: Carrott Et al.
    J Pharmacol Exp Ther  2016;36:222
  4. Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
    Authors: Ghezzi Et al.
    Neuroscience  2016;340:62
  5. Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
    Authors: Sedivy Et al.
    Am J Physiol Lung Cell Mol Physiol  2015;308:L48
  6. Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea.
    Authors: Zampini Et al.
    PLoS One  2014;9:e113750
  7. Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
    Authors: Lee Et al.
    Int J Mol Sci  2014;15:977
  8. Burst activity and ultrafast activation kinetics of CaV1.3 Ca2+ channels support presynaptic activity in adult gerbil hair cell ribbon synapses.
    Authors: Zampini Et al.
    Front Cell Neurosci  2013;591:3811
  9. Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex.
    Authors: Gigout Et al.
    BMC Neurosci  2012;13:42
  10. KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle.
    Authors: Joshi Et al.
    J Physiol  2009;329:368


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