Catalog Number: 1776
Biological Activity
Control peptide version of dynamin inhibitory peptide, myristoylated (Cat. No. 1775), an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Gln-1 = Myr-Gln, Arg-10 = C-terminal amide)

  • Solubility:
    Soluble to 0.67 mg/ml in 30% acetonitrile / water
  • Storage:
    Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.
    Kittler et al.
    J.Neurosci., 2000;20:7972
  2. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
    Grabs et al.
    J.Biol.Chem., 1997;272:13419
  3. Glycine binding primes NMDA receptor internalization.
    Nong et al.
    Nature, 2003;422:302

The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated (control) include:

Showing Results 1 - 1 of 1

  1. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    J Neuroinflammation
Tocris Peptides
Description Application Cat# Citations Images  

Dynamin inhibitory peptide, myristoylated

1775 4  
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