Catalog Number: 1775
Biological Activity

Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.

Control Peptide also available.
Technical Data
  • M.Wt:
    1330.64
  • Formula:
    C61H107N19O14
  • Sequence:
    QVPSRPNRAP

    (Modifications: Gln-1 = Myr-Gln, Pro-10 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    251634-22-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.
    Kittler et al.
    J.Neurosci., 2000;20:7972
  2. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
    Grabs et al.
    J.Biol.Chem., 1997;272:13419
  3. Glycine binding primes NMDA receptor internalization.
    Nong et al.
    Nature, 2003;422:302
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated include:

4 Citations: Showing 1 - 4
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  1. Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes.
    Authors: Preta Et al.
    FASEB J 2015;29:1516
  2. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    PLoS One 2015;10:e0131430
  3. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.
    Authors: Kolpak Et al.
    Circ Res 2009;29:10488
  4. Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor.
    Authors: Choi Et al.
    PLoS One 2005;97:363
Tocris Peptides
Description Application Cat# Citations Images  

Dynamin inhibitory peptide, myristoylated (control)

1776 1  
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