Dynamin inhibitory peptide

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Dynamin inhibitory peptide
1 Image
Description: Dynamin inhibitor
Alternative Names: P4

Purity: ≥95%

Product Details
Citations (13)

Biological Activity

Dynamin inhibitory peptide is a peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.

Cell-permeable version also available.

Technical Data

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Dynamin inhibitory peptide

The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:

13 Citations: Showing 1 - 10

  1. Clathrin-independent trafficking of AMPA receptors.
    Authors: Glebov Et al.
    J Biol Chem  2015;35:4830
  2. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
    Authors: Pleil Et al.
    Nat Neurosci  2015;18:545
  3. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    J Neurosci  2015;10:e0131430
  4. Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.
    Authors: Chiang Et al.
    Nat Commun  2014;5:3356
  5. Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
    Authors: Yuen Et al.
    J Biol Chem  2014;289:25177
  6. Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
    Authors: Chamma Et al.
    J Neurosci  2013;33:15488
  7. Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents.
    Authors: Zhu Et al.
    J Neurophysiol  2012;108:2581
  8. Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.
    Authors: Cuitino Et al.
    PLoS One  2010;30:8411
  9. DA D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
    Authors: Graziane Et al.
    J Neurosci  2009;284:8329
  10. Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway.
    Authors: Dewerchin Et al.
    J Gen Virol  2008;89:2731


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