Dynamin inhibitory peptide

  ( 12 citations )    
Product Datasheet
Catalog Number:1774
Alternate Names:P4
Chemical Name:
Product Details
Citations (12)
Reviews
Biological Activity
Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.

Cell-permeable version also available.

Technical Data
  • M.Wt:
    1121.26
  • Formula:
    C47H80N18O14
  • Sequence:
    QVPSRPNRAP
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    251634-21-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:

12 Citations: Showing 1 - 10
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  1. Clathrin-independent trafficking of AMPA receptors.
    Authors: Glebov Et al.
    J Biol Chem  2015;35:4830
  2. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
    Authors: Pleil Et al.
    Nat Neurosci  2015;18:545
  3. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    J Neurosci  2015;10:e0131430
  4. Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.
    Authors: Chiang Et al.
    Nat Commun  2014;5:3356
  5. Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
    Authors: Chamma Et al.
    J Neurosci  2013;33:15488
  6. Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents.
    Authors: Zhu Et al.
    J Neurophysiol  2012;108:2581
  7. Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.
    Authors: Cuitino Et al.
    PLoS One  2010;30:8411
  8. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
    Authors: Graziane Et al.
    J Neurosci  2009;284:8329
  9. Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway.
    Authors: Dewerchin Et al.
    J Gen Virol  2008;89:2731
  10. In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.
    Authors: Grueter Et al.
    J Neurosci  2008;28:9261
  11. Activity-dependent synaptic plasticity in retinal ganglion cells.
    Authors: Xia Et al.
    J Neurosci  2007;27:12221
  12. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism.
    Authors: Jiang Et al.
    J Neurosci  2006;26:4318
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