Catalog Number: 1774
Alternate Names: P4
Biological Activity
Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.

Cell-permeable version also available.

Technical Data
  • M.Wt:
    1121.26
  • Formula:
    C47H80N18O14
  • Sequence:
    QVPSRPNRAP
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    251634-21-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.
    Kittler et al.
    J.Neurosci., 2000;20:7972
  2. The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
    Grabs et al.
    J.Biol.Chem., 1997;272:13419
  3. Glycine binding primes NMDA receptor internalization.
    Nong et al.
    Nature, 2003;422:302
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:

8 Citations: Showing 1 - 8
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  1. Clathrin-independent trafficking of AMPA receptors.
    Authors: Glebov Et al.
    J Biol Chem 2015;35:4830
  2. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
    Authors: Pleil Et al.
    Nat Neurosci 2015;18:545
  3. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    J Neurosci 2015;10:e0131430
  4. Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.
    Authors: Chiang Et al.
    Nat Commun 2014;5:3356
  5. Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.
    Authors: Cuitino Et al.
    PLoS One 2010;30:8411
  6. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
    Authors: Graziane Et al.
    J Neurosci 2009;284:8329
  7. Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway.
    Authors: Dewerchin Et al.
    J Gen Virol 2008;89:2731
  8. Activity-dependent synaptic plasticity in retinal ganglion cells.
    Authors: Xia Et al.
    J Neurosci 2007;27:12221

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