Biological ActivityPeptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.
Cell-permeable version also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
Grabs et al.
Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.
Kittler et al.
Glycine binding primes NMDA receptor internalization.
Nong et al.
Citations for Dynamin inhibitory peptide
The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:
13 Citations: Showing 1 - 10
Clathrin-independent trafficking of AMPA receptors.
Authors: Glebov Et al.
J Biol Chem 2015;35:4830
NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
Authors: Pleil Et al.
Nat Neurosci 2015;18:545
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
J Neurosci 2015;10:e0131430
Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.
Authors: Chiang Et al.
Nat Commun 2014;5:3356
Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
Authors: Yuen Et al.
J Biol Chem 2014;289:25177
Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
Authors: Chamma Et al.
J Neurosci 2013;33:15488
Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents.
Authors: Zhu Et al.
J Neurophysiol 2012;108:2581
Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.
Authors: Cuitino Et al.
PLoS One 2010;30:8411
DA D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
Authors: Graziane Et al.
J Neurosci 2009;284:8329
Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway.
Authors: Dewerchin Et al.
J Gen Virol 2008;89:2731
In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.
Authors: Grueter Et al.
J Neurosci 2008;28:9261
Activity-dependent synaptic plasticity in retinal ganglion cells.
Authors: Xia Et al.
J Neurosci 2007;27:12221
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
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