Chemical Name: N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide
Biological ActivityHighly potent, selective OX2 receptor antagonist (IC50 values are 2.3 nM and 1900 nM for OX2 and OX1 respectively). Displays negligible or no inhibition of a panel of 80 receptors. Blocks orexin-B- and orexin-A-invoked calcium mobilization in hOX2-expressing CHO cells (IC50 values are 7.9 nM and 8.8 nM respectively); reverses orexin-B-induced hyperlocomotion in mice. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor.
Malherbe et al.
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice.
Mochizuki et al.
Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-
Malherbe et al.
Citations for EMPA
The citations listed below are publications that use Tocris products. Selected citations for EMPA include:
2 Citations: Showing 1 - 2
The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine.
Authors: Guerreiro Et al.
Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamus.
Authors: Beig Et al.
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