Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
Biological ActivityHigh affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Epibatidine, a potent analgesic and nicotinic agonist.
Badio and Daly
Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors.
Gerzarich et al.
Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain.
Marks et al.
UB-165 implicates α4β2 nAChR in striatal DA release.
Sharples et al.
Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity.
Spande et al.
Citations for (±)-Epibatidine
The citations listed below are publications that use Tocris products. Selected citations for (±)-Epibatidine include:
2 Citations: Showing 1 - 2
The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens.
Authors: Williams Et al.
Br J Pharmacol 2007;150:906
Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells.
Authors: Beckel Et al.
J Neurosci 2006;290:F103
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