Catalog Number: 0684
Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
Biological Activity
High affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in water and to 100 mM in ethanol
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the NIH, US Patent 5,314,899
Background References
  1. Epibatidine, a potent analgesic and nicotinic agonist.
    Badio and Daly
    Mol.Pharmacol., 1994;45:563
  2. Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors.
    Gerzarich et al.
    Mol.Pharmacol., 1995;48:774
  3. Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain.
    Marks et al.
    J.Pharmacol.Exp.Ther., 1998;285:377
  4. UB-165 implicates α4β2 nAChR in striatal dopamine release.
    Sharples et al.
    J.Neurosci., 2000;20:2783
  5. Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity.
    Spande et al.
    J.Am.Chem.Soc., 1992;114:3475

The citations listed below are publications that use Tocris products. Selected citations for (±)-Epibatidine include:

1 Citations: Showing 1 - 1

  1. Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells.
    Authors: Beckel Et al.
    J Neurosci 2006;290:F103

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