Catalog # Availability Size / Price Qty
(±)-Epibatidine | CAS No. 148152-66-3 | Additional Nicotinic Receptor Agonists
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Description: High affinity nAChR agonist

Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

(±)-Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.

Technical Data

Soluble to 5 mM in water and to 100 mM in ethanol
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the NIH, US Patent 5,314,899

Background References

  1. Epibatidine, a potent analgesic and nicotinic agonist.
    Badio and Daly
    Mol.Pharmacol., 1994;45:563
  2. Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors.
    Gerzarich et al.
    Mol.Pharmacol., 1995;48:774
  3. Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain.
    Marks et al.
    J.Pharmacol.Exp.Ther., 1998;285:377
  4. UB-165 implicates α4β2 nAChR in striatal DA release.
    Sharples et al.
    J.Neurosci., 2000;20:2783
  5. Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity.
    Spande et al.
    J.Am.Chem.Soc., 1992;114:3475

Product Datasheets

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Citations for (±)-Epibatidine

The citations listed below are publications that use Tocris products. Selected citations for (±)-Epibatidine include:

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