Catalog Number: 6100
Chemical Name: N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
Biological Activity
GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.
    Schimmer et al.
    Cancer.Res., 2006;66:2367
  2. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.
    Wood et al.
    Mol.Cancer.Ther., 2008;7:3546
  3. Anticancer agents interacting with membrane glucose transporters.
    Granchi et al.
    Med.Chem.Comm., 2016;7:1716
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