Fasentin

Key Product Details

Product Description

Fasentin is a GLUT1 and GLUT4 inhibitor (IC₅₀ = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC₅₀ = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.

Product Specifications for Fasentin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fasentin

The following data is based on the product molecular weight 279.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.58 mL	17.88 mL	35.76 mL
5 mM	0.72 mL	3.58 mL	7.15 mL
10 mM	0.36 mL	1.79 mL	3.58 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Wood A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol.Cancer.Ther. 2008 PMID: 19001437
• Granchi Anticancer agents interacting with membrane glucose transporters. Med.Chem.Comm. 2016 PMID: 28042452
• Schimmer Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer.Res. 2006 PMID: 16489043

Product Documents for Fasentin