GLUT1 and GLUT4 inhibitor (IC50
= 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50
= 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.
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All Tocris products are intended for laboratory research use only.
Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.
Schimmer et al.
A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death.
Wood et al.
Anticancer agents interacting with membrane glucose transporters.
Granchi et al.