hh Fenoldopam hydrochloride (CAS 181217-39-0): R&D Systems
Catalog Number: 1659
Alternate Names: SKF 82526
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrochloride
Biological Activity
Selective D1-like dopamine receptor partial agonist (EC50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).
Technical Data
  • M.Wt:
    342.22
  • Formula:
    C16H16ClNO3.HCl
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    181217-39-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
Background References
  1. Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist.
    Hahn et al.
    J.Pharmacol.Exp.Ther., 1982;223:305
  2. The pharmacology of fenoldopam.
    Nichols et al.
    Am.J.Hypertens., 1990;3:116S
  3. Interactions of novel dopaminergic ligands with D-1 and D-2 dopamine receptors.
    Sibley et al.
    Life Sci., 1982;31:637
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fenoldopam hydrochloride include:

1 Citations: Showing 1 - 1

  1. Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis.
    Authors: Chen Et al.
    Hypertension 2013;62:927

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