Catalog Number: 1470
Chemical Name: N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
Biological Activity
Open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.
Technical Data
  • M.Wt:
    474.4
  • Formula:
    C17H20F6N2O3.C2H4O2
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    54143-56-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides.
    Banitt et al.
    J.Med.Chem., 1977;20:821
  2. The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions.
    Singh et al.
    Ann.N.Y.Acad.Sci., 1984;17:251
  3. Use-and concentration-dependent effects of flecainide in guinea pig right ventricular muscle.
    Rouet and Ducouret
    J.Cardiovasc.Pharmacol., 1994;24:177
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Flecainide acetate include:

1 Citations: Showing 1 - 1

  1. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.
    Authors: Yu Et al.
    J Neurosci 2014;9:e96691

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