Floxuridine

Catalog # Availability Size / Price Qty
4659/50

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Floxuridine | CAS No. 50-91-9 | Thymidylate Synthetase Inhibitor
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Description: Thymidylate synthetase inhibitor
Alternative Names: FdUrd

Chemical Name: 5-Fluoro-2'-deoxyuridine

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Floxuridine is an antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

Technical Data

M.Wt:
246.19
Formula:
C9H11FN2O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
50-91-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.
    Huehls AM, Wagner JM, Huntoon CJ, Geng L, Erlichman C, Patel AG, Kaufmann SH, Karnitz LM
    Cancer Res., 2011;71(14):4944-54.
  2. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
    Bapat et al.
    J.Biol.Chem., 1983;258:4130
  3. Participation of DNA repair in the response to 5-fluorouracil.
    Wyatt and Wilson
    Cell.Mol.Life Sci., 2009;66:788

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Citation for Floxuridine

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