Catalog Number: 4659
Alternate Names: FdUrd
Chemical Name: 5-Fluoro-2'-deoxyuridine
Biological Activity
Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.
    Huehls AM, Wagner JM, Huntoon CJ et al.
    Cancer Res.
  2. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
    Bapat et al.
    J.Biol.Chem., 1983;258:4130
  3. Participation of DNA repair in the response to 5-fluorouracil.
    Wyatt and Wilson
    Cell.Mol.Life Sci., 2009;66:788
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