Discontinued Product

4659 has been discontinued.
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Floxuridine | CAS No. 50-91-9 | Thymidylate Synthetase Inhibitor
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Description: Thymidylate synthetase inhibitor
Alternative Names: FdUrd

Chemical Name: 5-Fluoro-2'-deoxyuridine

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

Floxuridine is an antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
    Bapat et al.
    J.Biol.Chem., 1983;258:4130
  2. Participation of DNA repair in the response to 5-fluorouracil.
    Wyatt and Wilson
    Cell.Mol.Life Sci., 2009;66:788
  3. Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.
    Huehls AM, Wagner JM, Huntoon CJ, Geng L, Erlichman C, Patel AG, Kaufmann SH, Karnitz LM
    Cancer Res., 2011-05-25;71(14):4944-54.

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Floxuridine

The citations listed below are publications that use Tocris products. Selected citations for Floxuridine include:

1 Citation: Showing 1 - 1


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