Chemical Name: 5-Fluoro-2'-deoxyuridine
Biological ActivityFloxuridine is an antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.
Huehls AM, Wagner JM, Huntoon CJ, Geng L, Erlichman C, Patel AG, Kaufmann SH, Karnitz LM
Cancer Res., 2011;71(14):4944-54.
Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
Bapat et al.
Participation of DNA repair in the response to 5-fluorouracil.
Wyatt and Wilson
Cell.Mol.Life Sci., 2009;66:788
Citation for Floxuridine
The citations listed below are publications that use Tocris products. Selected citations for Floxuridine include:
1 Citation: Showing 1 - 1
Zika virus infection reprograms global transcription of host cells to allow sustained infection.
Authors: Tiwari Et al.
Emerg Microbes Infect 2017;6:e24
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