Catalog Number: 1768
Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Biological Activity
Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.
Technical Data
  • M.Wt:
    458.55
  • Formula:
    C26H34O7
  • Solubility:
    Soluble to 3 mM in ethanol
  • Storage:
    Store at -20°C
  • CAS No:
    23110-15-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase.
    Lowther et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:12153
  2. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth.
    Ingber et al.
    Nature, 1990;348:555
  3. Cytochemical evidence for RNA synthesis inhibition by fumagillin.
    Jaronski
    J.Antibiot., 1972;25:327
  4. A re-evaluation of fumagillin selectivity towards endothelial cells.
    Rodriguez-Nieto et al.
    Anticancer Res., 2001;21:3457
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Fumagillin include:

1 Citations: Showing 1 - 1

  1. A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization.
    Authors: Palmer Et al.
    Br J Pharmacol 2012;165:1891

Have you used Fumagillin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information