Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro
and tumor-induced angiogenesis in vivo
. Also inhibits tumor growth in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase.
Lowther et al.
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth.
Ingber et al.
Cytochemical evidence for RNA synthesis inhibition by fumagillin.
A re-evaluation of fumagillin selectivity towards endothelial cells.
Rodriguez-Nieto et al.
Anticancer Res., 2001;21:3457
The citations listed below are publications that use Tocris products. Selected citations for Fumagillin include:
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