G-Protein antagonist peptide
Biological Activity
Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.Technical Data
(Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.
Mukai et al.
J.Biol.Chem., 1992;267:16237
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Citations for G-Protein antagonist peptide
The citations listed below are publications that use Tocris products. Selected citations for G-Protein antagonist peptide include:
2 Citations: Showing 1 - 2
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A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
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Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.
Authors: Nogueras-Ortiz
Mol Biol Cell 2017;28(24):3554
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