7 results for "G Protein (Heterotrimeric) Inhibitors" in Products
G Protein (Heterotrimeric) Inhibitors
Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an α-, β- and γ-subunit and is bound to GDP in the 'off' state. Ligand binding to a 7-TM receptor causes a conformational change in the receptor, which detaches the G protein. This switches the G protein to an 'on' state, allowing GTP to displace GDP, thus Gα can activate second messenger signaling cascades.
There are several types of Gα ...
Catalyzes ADP-ribosylation of Gi, Go and Gt
Inhibitor of Gβ/γ signaling
| Chemical Name: | 3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one |
| Purity: | ≥95% |
Epac inhibitor
| Chemical Name: | α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile |
| Purity: | ≥98% |
Potent and selective GRK2/3 inhibitor
| Chemical Name: | 3-[[[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamide |
| Purity: | ≥98% |
Selective and competitive P2X1 antagonist
| Chemical Name: | 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt |
Inhibitor of ligand binding to G-protein-coupled receptors
| Chemical Name: | N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide |
| Purity: | ≥98% |
Inhibits Gs and stimulates Gi activity
| Purity: | ≥95% |
