Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Biological ActivityFluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase and S.aureus topoisomerase IV respectively). Displays potent activity against gram-positive and gram-negative bacteria. Stimulates short-term self-renewal in both human and mouse embryonic stem cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
High throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Desbordes et al.
Cell Stem Cell, 2008;2:602
Inhibitory activities of gatiflo. (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.
Takei et al.
Antimicrob.Agents Chemother., 1998;42:2678
Antibacterial activity of gatiflo. (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus.
Fukuda et al.
Antimicrob.Agents Chemother., 1998;42:1917
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Gatifloxacin was used to understand its resistance pattern against S. aureus. E. coli strains were grown in Luria-Bertani medium, and S. aureus strains were grown in brain heart infusion medium for resistance study.